Thermo Fisher Scientific STAT3 Polyclonal Antibody
STAT3 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Western blot, IHC, ICC, Flow Cytometry 등에 사용 가능. 인간 및 마우스 반응성. 0.5 mg/mL 농도, 액상 형태로 -20°C 보관. 세포 성장 및 신호전달 연구에 적합.
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Thermo Fisher Scientific STAT3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | - |
| Immunohistochemistry (Paraffin) (IHC-P) | 6–7 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus amino acids DMELTSECATSPM (aa 758–770) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2198606 |
Product Specific Information
- Predicted to react with bovine, canine, and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins. These are phosphorylated by receptor-associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for transcriptional activation by STAT3.
STAT3 can be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF, and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding. The STAT3 gene is located on the q arm of chromosome 17 in humans.
STAT3 mediates the expression of various genes in response to stimuli, playing a key role in cellular processes such as growth and apoptosis. Rac1 binds and regulates STAT3 activity, while PIAS3 acts as a specific inhibitor. Three alternatively spliced transcript variants encoding distinct isoforms have been described. Deletion of STAT3 in knock-out mice is lethal at the early embryonic stage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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