Thermo Fisher Scientific PSMD2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PSMD2 protein. Validated for WB and ICC/IF applications. High specificity with predicted cross-reactivity across multiple species. Supplied as unconjugated liquid, affinity purified, and suitable for research ...
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: View 2 publications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 504–786 of Human PSMD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.82 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545139 |
Product Specific Information
- Recommended positive controls: A431, JC, BCL-1
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (91%), Xenopus laevis (92%), Pig (100%), Chicken (97%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The 26S proteasome is a multicatalytic proteinase complex composed of two major assemblies: the 20S core and the 19S regulator.
- 20S Core: 4 rings of 28 non-identical subunits (two rings of 7 alpha subunits and two rings of 7 beta subunits)
- 19S Regulator: Base with 6 ATPase and 2 non-ATPase subunits, and a lid with up to 10 non-ATPase subunits
Proteasomes are widely distributed throughout eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome plays an essential role in processing class I MHC peptides.
This gene encodes one of the non-ATPase subunits of the 19S regulator lid and may also participate in TNF signaling through interaction with TNF type 1 receptor.
A pseudogene has been identified on chromosome 1.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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