Thermo Fisher Scientific TDG Monoclonal Antibody (GT1511)
TDG 단백질을 인식하는 Mouse monoclonal antibody (Clone GT1511). Western blot과 IHC(Paraffin)에 적합하며, Human, Mouse, Rat에 반응. Protein A로 정제된 액상 항체로 1 mg/mL 농도. 연구용으로만 사용 가능.
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- MA531522
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- pk
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT1511 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TDG |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787153 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Human (99%), Mouse (88%), Rat (87%), Bovine (91%).
- Positive Control: human TDG-transfected 293T cells.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family.
Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine.
With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine.
This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.
This gene may have a pseudogene in the p arm of chromosome 12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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