Thermo Fisher Scientific Leptin Receptor Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:1,000

Product Specifications

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily that plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of OB-R by the adipose tissue-secreted hormone leptin triggers downstream signaling through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway.

Leptin can homo-dimerize OB-R extracellular domains, and signaling is initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of OB-R differing in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and hypothalamus, proposed as control centers for satiety and energy expenditure.

Mutations in either the mouse OB-R (db) or leptin (ob) genes result in early-onset obesity. Metabolic abnormalities associated with these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and increased white adipose tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.