Thermo Fisher Scientific Leptin Receptor Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily that plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of OB-R by the adipose tissue-secreted hormone leptin triggers downstream signaling through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains, initiating signaling via intracellular domain dimerization. Several isoforms of OB-R, differing in length and signaling capability, have been reported. RNA transcripts encoding the OB-R long form are found in the choroid plexus and hypothalamus, regions associated with satiety and energy expenditure control. Mutations in OB-R (db) or leptin (ob) genes in mice lead to early-onset obesity and related metabolic abnormalities such as hyperinsulinemia, insulin resistance, hyperglycemia, and increased adipose tissue.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.