Thermo Fisher Scientific 4EBP1 Monoclonal Antibody (11G12C11)
4EBP1 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot, IHC, ELISA에 적합. Human 시료 반응성 확인됨. 장기 보관 시 -20°C 권장, 연구용 전용.
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Thermo Fisher Scientific 4EBP1 Monoclonal Antibody (11G12C11)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 11G12C11 |
| Immunogen | Purified recombinant fragment of 4EBP1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982717 |
Product Specific Information
MA5-15314 targets 4E-BP1 in indirect ELISA, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15314 immunogen is purified recombinant fragment of 4EBP1 expressed in E. coli.
Target Information
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNAs.
Interaction of this protein with eIF4E inhibits complex assembly and represses translation.
This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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