Thermo Fisher Scientific FOLH1 Monoclonal Antibody (UMAB27), UltraMAB
FOLH1(PSMA) 단백질을 인식하는 UMAB27 클론의 단일클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제 및 안정한 저장용 버퍼를 포함합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB27 |
| Immunogen | Full length human recombinant protein of human FOLH1 produced in HEK293T cell. Target family: PSMA, UniProt ID: Q04609-1, Antigen range: 1–750 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on various substrates, including folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as the prostate, central and peripheral nervous systems, and kidney.
Mutations in this gene may cause impaired intestinal folate absorption, leading to low blood folate levels and hyperhomocysteinemia. Expression in the brain may be linked to glutamate excitotoxicity-related conditions. In the prostate, the protein is up-regulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer.
This gene likely originated from a chromosomal duplication event, and alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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