Thermo Fisher Scientific CAPNS2 Polyclonal Antibody
CAPNS2 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체. 인간, 마우스, 랫트에 반응하며 Western Blot에 적합. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상. 액상 형태로 제공되며 장기 보관 시 -20°C에서 보관 권장.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human CAPNS2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719463 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Purity is greater than 95% (by SDS-PAGE).
Target Information
The Calpain family of proteins are calcium-regulated thiol proteases with broad endopeptidase activity.
Calpain small subunit 2 (CSS2 or CAPNS2) is a calcium-dependent protease expressed ubiquitously in the cytoplasm.
It forms a heterodimer with a large subunit, catalyzing proteolysis of proteins involved in cytoskeletal remodeling and signal transduction.
CSS2 also acts as a chaperone for the larger subunit, ensuring proper folding and conformation.
Upon calcium binding, CSS2 dissociates from the complex, activating the large subunit and translocating to the cell membrane.
Defects in the CSS2 gene can lead to abnormal calpain activity and impaired fetal development, indicating its essential role in growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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