Thermo Fisher Scientific Factor 10 heavy chain Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. The two chains are held together by one or more disulfide bonds. The light chain contains two EGF-like domains, while the heavy chain contains the catalytic domain homologous to other hemostatic serine proteases. The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting. Mutations in this gene cause factor X deficiency, a hemorrhagic condition of variable severity.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.