Thermo Fisher Scientific ADAMTS4 Monoclonal Antibody (OTI6F1), TrueMAB
인간 ADAMTS4 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot에 1:2,000 희석으로 사용 가능. 액상 형태이며, PBS/BSA/glycerol 버퍼에 보존. 단백질 분해 관련 연구 및 신경계 질환 연구에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 296–577 of human ADAMTS4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the ADAMTS protein family. Members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
The enzyme encoded by this gene lacks a C-terminal TS motif and is responsible for the degradation of aggrecan (a major proteoglycan of cartilage) and brevican (a brain-specific extracellular matrix protein).
The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially in the progression of glioma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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