Thermo Fisher Scientific PDE4B Monoclonal Antibody (OTI3B12), TrueMAB
PDE4B 단백질을 인식하는 Mouse monoclonal antibody로 Western Blot, IHC, Flow Cytometry에 사용 가능. Human 시료에 반응하며, carrier-free 형식으로 제공되어 conjugation 실험에 적합. 동결건조 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B12 |
| Immunogen | Full length human recombinant protein of human PDE4B produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The PDE4B gene belongs to the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides serve as second messengers regulating various cellular responses to extracellular signals such as hormones, light, and neurotransmitters.
PDEs control cellular concentrations of cyclic nucleotides and thus play a crucial role in signal transduction.
PDE4B specifically hydrolyzes cAMP, and altered activity has been linked to schizophrenia and bipolar affective disorder.
Multiple splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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