Thermo Fisher Scientific A2M Polyclonal Antibody
Thermo Fisher Scientific의 A2M Polyclonal Antibody는 인간 Alpha 2-Macroglobulin을 인식하는 Rabbit IgG 항체로, Western blot에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 1% BSA와 20% glycerol이 포함되어 안정성이 우수합니다.
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Applications
- Western Blot (WB): 1:500–1:10,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 427–641 of Human alpha 2 Macroglobulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547060 |
Product Specific Information
- Recommended positive controls: 293T, A431, Jurkat, human plasma
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits. It shares structural features with other alpha-macroglobulins such as complement components C3, C4, and pregnancy zone protein (PZP), exhibiting broad ligand-binding capacity. This enables A2M to act as a humoral defense barrier against foreign peptides in plasma. A2M captures various proteinases, functioning as a panprotease inhibitor. In Alzheimer’s disease patients, A2M has been localized to diffuse amyloid plaques, suggesting its role in AD pathogenesis.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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