Thermo Fisher Scientific Zika Virus Envelope Protein Monoclonal Antibody (GT363)
지카 바이러스 Envelope 단백질을 인식하는 Mouse 단클론 항체(GT363). Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. 고순도 Protein A 정제, PBS buffer, 보존제 무첨가. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50–1:3,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| ELISA | 1:1,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT363 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of Zika virus Envelope protein (Zika virus strain H/PF/2013). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911487 |
Product Specific Information
- Store as concentrated solution.
- Centrifuge briefly prior to opening vial.
- For short-term storage (1–2 weeks), store at 4°C.
- For long-term storage, aliquot and store at -20°C or below.
- Avoid multiple freeze-thaw cycles.
Target Information
Zika virus (ZIKV), a member of the Flaviviridae family, possesses a single positive-sense RNA genome translated as a polyprotein, which is post-translationally cleaved into three structural proteins (C, PrM/M, and E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5).
The glycosylated NS1 forms a homodimer inside cells essential for viral replication and is later secreted as a hexameric lipoprotein particle. This secreted form contributes to immune evasion and viral pathogenesis by interacting with host innate and adaptive immune components.
References:
- Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456–458.
- Suthar, M.S.; Diamond, M.S.; Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115–128.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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