Thermo Fisher Scientific Zika Virus Envelope Protein Monoclonal Antibody (GT363)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store as concentrated solution.
• Centrifuge briefly prior to opening vial.
• For short-term storage (1–2 weeks), store at 4°C.
• For long-term storage, aliquot and store at -20°C or below.
• Avoid multiple freeze-thaw cycles.

Target Information

Zika virus (ZIKV), a member of the Flaviviridae family, possesses a single positive-sense RNA genome translated as a polyprotein, which is post-translationally cleaved into three structural proteins (C, PrM/M, and E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5).
The glycosylated NS1 forms a homodimer inside cells essential for viral replication and is later secreted as a hexameric lipoprotein particle. This secreted form contributes to immune evasion and viral pathogenesis by interacting with host innate and adaptive immune components.

References:

1. Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456–458.
2. Suthar, M.S.; Diamond, M.S.; Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115–128.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.