Thermo Fisher Scientific ALK Monoclonal Antibody (OTI3C8), TrueMAB
인간 ALK 단백질을 표적으로 하는 Mouse IgG2a 단일클론 항체로, Western blot에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보관되며 -20°C에서 안정적입니다. 뇌 발달 및 종양 연구용으로 사용됩니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement between the ALK gene (chromosome 2) and NPM gene (chromosome 5) produces an oncogenic fusion protein (NPM-ALK). The ALK protein features a transmembrane and extracellular domain, which are absent in the NPM-ALK fusion product. ALK shows high sequence similarity to LTK and plays a key role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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