Thermo Fisher Scientific ALK Monoclonal Antibody (OTI2H8), TrueMAB
인간 ALK 단백질(aa 1300-1620)을 인식하는 Mouse IgG2a 단클론 항체. Western blot에 최적화되어 있으며, 액상 형태로 1 mg/mL 농도 제공. 뇌 발달 연구 및 종양 관련 ALK 변이 분석에 적합. 연구용으로만 사용 가능.
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Applications
Tested Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with several tumors including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement commonly produces a fusion gene between ALK (chromosome 2) and nucleophosmin (NPM, chromosome 5). The resulting NPM-ALK fusion protein is oncogenic.
ALK encodes a receptor tyrosine kinase with a transmembrane and extracellular domain, absent in the NPM-ALK fusion product. It shows the greatest sequence similarity to LTK and functions in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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