Thermo Fisher Scientific F4/80 Polyclonal Antibody
Rabbit polyclonal antibody targeting human F4/80 (EMR1) for IHC-P applications. Recognizes macrophage marker with high species homology. Supplied as liquid, 1 mg/mL, purified by antigen affinity chromatography. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC-P): 10–20 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminal extracellular domain of human EMR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550882 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Gibbon: 93%
- Monkey: 87%
- Marmoset, Mouse, Rat, Pig, Platypus: 80%
Target Information
F4/80 antigen is a 160 kDa cell surface glycoprotein belonging to the EGF-TM7 family, sharing 68% amino acid identity with human EMR1. Expression varies during macrophage maturation and activation. It is present on mature tissue macrophages such as Kupffer cells, Langerhans cells, microglia, and macrophages in the gut, peritoneal cavity, lung, thymus, bone marrow stroma, and spleen red pulp. F4/80 is also expressed on some dendritic cells but absent from macrophages in T cell areas of spleen and lymph nodes. Though its ligands and functions are not fully defined, studies suggest a role in generating efferent CD8⁺ regulatory T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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