Thermo Fisher Scientific F4/80 Polyclonal Antibody
Rabbit polyclonal antibody targeting human F4/80 (EMR1) for IHC applications. High specificity and affinity purified. Suitable for macrophage marker studies. Provided as liquid form, 1 mg/mL, stored at 4°C or -20°C.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 10–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from C-terminus of human EMR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550884 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human (100%)
- Gorilla, Marmoset (89%)
- Gibbon (83%)
Target Information
F4/80 antigen is a 160 kDa cell surface glycoprotein belonging to the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EMR1.
Expression of F4/80 varies during macrophage maturation and activation. It is found on mature tissue macrophages including Kupffer cells, Langerhans cells, microglia, macrophages in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma, and red pulp of the spleen.
F4/80 is also expressed on some dendritic cells but absent from macrophages in T cell areas of spleen and lymph node.
Its ligands and biological functions are not fully determined, but studies suggest involvement in generation of efferent CD8⁺ regulatory T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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