Thermo Fisher Scientific F4/80 Polyclonal Antibody
Rabbit polyclonal antibody targeting human F4/80 antigen for macrophage detection. Validated for IHC and ELISA. High specificity and purity via antigen affinity chromatography. Suitable for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 18–36 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EMR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550883 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human: 100%
- Gorilla: 89%
Target Information
F4/80 antigen is a 160 kDa cell surface glycoprotein belonging to the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EMR1.
Expression of F4/80 varies during macrophage maturation and activation. It is present on a wide range of mature tissue macrophages including:
- Kupffer cells
- Langerhans cells
- Microglia
- Gut lamina propria macrophages
- Peritoneal cavity macrophages
- Lung, thymus, bone marrow stroma macrophages
- Red pulp macrophages of the spleen
Additionally, F4/80 expression has been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node.
The ligands and biological functions of F4/80 are not yet fully determined, but recent studies suggest its role in the generation of efferent CD8⁺ regulatory T cells.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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