Thermo Fisher Scientific OGG1 Polyclonal Antibody
OGG1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(PFA fixed)에 사용 가능. Human, Mouse, Rat 등 다양한 종에 반응. Affinity chromatography로 정제되었으며, PBS와 50% glycerol buffer에 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human OGG1 (Accession O15527), corresponding to amino acid residues S280–G300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900320 |
Product Specific Information
Antibody detects endogenous levels of total OGG1.
Target Information
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue.
hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds controlling the repair of damaged DNA are involved in susceptibility to cancer development.
The hOgg1 gene has been mapped to region 3p26.2, a region showing loss of heterozygosity (LOH) in various cancers. In particular, 3p25–p26 is a common LOH region in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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