Thermo Fisher Scientific SLC22A5 Polyclonal Antibody
SLC22A5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat에서 반응하며, 고순도 Affinity chromatography로 정제되었습니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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- PA5102460
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC22A5 (Accession O76082), corresponding to amino acid residues M445–M495 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851864 |
Product Specific Information
Antibody detects endogenous levels of total SLC22A5.
Target Information
Carnitine (β-hydroxy-γ-trimethylaminobutyrate) is a small, highly polar compound that aids in the β-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells.
OCTN1 is expressed in kidney, trachea, bone marrow, and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta, and heart. OCTN3 is strongly expressed in testis and weakly in kidney.
Mutations in the gene encoding OCTN2 lead to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia, and hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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