Thermo Fisher Scientific CD244 Polyclonal Antibody
CD244(2B4, SLAMF4)을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 Immunocytochemistry에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 냉장 또는 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the carboxy terminus of human SLAMF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154333 |
Product Specific Information
- Suggested positive control: Daudi cell lysate
- PA5-21136 can be used with blocking peptide PEP-1250
Target Information
CD244 (also known as 2B4 or SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells and some T cells. It mediates non-MHC restricted cytotoxicity, modulating NK-cell activity through interaction with SLAMF2.
Reduced SLAMF4 expression has been observed in NK cells and monocytes of patients with systemic lupus erythematosus, suggesting a role in autoimmune disease pathology.
CD244 dysfunction is associated with conditions such as rheumatoid arthritis and lymphoproliferative syndrome.
Alternative splicing produces multiple isoforms of CD244.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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