Thermo Fisher Scientific Bcl-W Recombinant Rabbit Monoclonal Antibody (003)

Thermo Fisher Scientific Bcl-W Recombinant Rabbit Monoclonal Antibody (Clone 003)

Applications

• ELISA

Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

Specificity: Human Bcl-W/BCL2L2

Target Information

Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The rox portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.