Thermo Fisher Scientific PAI1 Polyclonal Antibody
Rabbit polyclonal antibody against Human PAI1, validated for WB and IHC-P. High purity (>95%) and antigen affinity purified. Supplied in PBS with sodium azide, 1 mg/mL concentration. Ideal for detecting PAI1 in human, mouse, and rat samples.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 281–330 of Human PAI-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2803343 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
PAI1 (plasminogen activator inhibitor 1) belongs to the serine protease inhibitor superfamily and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of circulating PAI1, but it is also synthesized and secreted by fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells.
Expression of PAI1 can be regulated by growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, and environmental factors. Elevated PAI1 levels are associated with thrombosis, obesity, thrombophilia, and metabolic syndrome.
Defects in PAI1 can cause abnormal bleeding or plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). PAI1 mediates inhibition of fibrinolysis and may promote neuronal survival. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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