Thermo Fisher Scientific Endothelin 3 Polyclonal Antibody
Endothelin 3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P)에서 사용 가능. Human, Mouse, Rat에 반응하며, Affinity Chromatography로 정제됨. PBS/glycerol buffer에 보관되며, -20°C에서 안정적 저장 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EDN3 (Accession P14138), corresponding to amino acid residues A186–G236 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854524 |
Product Specific Information
Antibody detects endogenous levels of total EDN3.
Target Information
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in various biological functions. The active form of this protein is a 21-amino acid peptide processed from a precursor protein and acts as a ligand for endothelin receptor type B (EDNRB). This interaction is essential for the development of neural crest-derived cell lineages such as melanocytes and enteric neurons. Mutations in this gene and EDNRB are associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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