Thermo Fisher Scientific A-Raf Polyclonal Antibody
Rabbit polyclonal antibody against human A-Raf protein. Validated for Western blot and immunocytochemistry. Supplied as liquid, unconjugated form with antigen affinity purification. Ideal for research on MAP kinase signaling pathways.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARAF. Recombinant protein control fragment (Product #RP-104815). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790963 |
Product Specific Information
Immunogen sequence:
DSNLIQLTGQ SFSTDAAGSR GGSDGTPRGS PSPASVSSGR KSPHSKSPAE QRERKSLADD KKKVKNLGYR DS
Target Information
Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk), and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity and is broadly expressed in nearly all cell lines tested to date. It is the cellular homolog of v-Raf, the transforming gene product of the 3611 strain of murine sarcoma virus.
The unregulated kinase activity of v-Raf is associated with transformation and mitogenesis, while Raf-1 activity is normally suppressed by a regulatory N-terminal domain.
A-Raf, a second member of the Raf gene family, exhibits substantial homology to Raf-1 within the kinase domain, but less elsewhere. Expression of A-Raf is highest in urogenital tissues and kidney, and lowest in brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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