Thermo Fisher Scientific PTPN2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PTPN2, validated for WB, IHC, and ICC applications. High specificity recombinant immunogen-based antibody. Supplied as liquid, unconjugated form with 0.1 mg/mL concentration. Suitable for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PTPN2. Recombinant protein control fragment (Product #RP-96580). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790962 |
Product Specific Information
Immunogen sequence:
PAFDHSPNKI MTEKYNGNRI GLEEEKLTGD RCTGLSSKMQ DTMEENSESA LRKRIREDRK ATTAQKVQQM KQRLNENERK RKRWLYWQP
Target Information
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations.
The shorter 45 kDa isoform is exclusively nuclear in resting cells but redistributes to the cytosol upon stimulation with growth factors and cellular stress.
The longer 48 kDa isoform is found in the endoplasmic reticulum and has distinctly different physiologic substrates from the smaller isoform.
Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP die 3–5 weeks after birth due to erythropoietic and lymphopoietic deficits, indicating a critical role for TC-PTP in bone marrow maturation.
TC-PTP dephosphorylates a wide range of phosphoproteins, including p52 Shc and receptors for EGF, Insulin, and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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