Thermo Fisher Scientific TOP2A Monoclonal Antibody (UMAB146), UltraMAB
TOP2A 단백질을 인식하는 Mouse monoclonal 항체로, Western blot과 IHC(P)에서 사용 가능. 인간 시료에 반응하며, 고순도 Affinity chromatography로 정제됨. 세포주기 연구 및 종양 세포 약제 내성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB146 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1100–1531 of human TOP2A produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Topo II alpha plays important roles in DNA synthesis and transcription, as well as chromosomal segregation during mitosis.
It is a sensitive and specific marker of late S-, G2-, and M-phases in transformed and developmentally regulated normal cells.
Topo II alpha is also implicated in drug resistance of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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