Thermo Fisher Scientific OLFM1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 90-220 of human OLFM1 (NP_0550941) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OLFM1,uniProtId:Q99784-1,ncbiNodeId:9606,antigenRange:90-220,antigenLength:485,antigenImageFileName:PA5-87397_OLFM1_Q99784-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87397_OLFM1_Q99784-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804117

Product Specific Information

Immunogen sequence: IEVLDRRTQR DLQYVEKMEN QMKGLESKFK QVEESHKQHL ARQFKAIKAK MDELRPLIPV LEEYKADAKL VLQFKEEVQN LTSVLNELQE EIGAYDYDEL QSRVSNLEER LRACMQKLAC GKLTGISDPV T; Positive Samples: Mouse brain, MCF7, A-549, SW480; Cellular Location: Cell junction, Cell projection, Endoplasmic reticulum, Perikaryon, axon, synapse

Target Information

The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.