Thermo Fisher Scientific OLFM1 Polyclonal Antibody
OLFM1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot과 ELISA에 적합하며, 인간과 생쥐 샘플에서 반응. 신경계 발달 관련 연구에 활용 가능. 액상 형태, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 90–220 of human OLFM1 (NP_055094.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804117 |
Product Specific Information
Immunogen sequence:
IEVLDRRTQR DLQYVEKMEN QMKGLESKFK QVEESHKQHL ARQFKAIKAK MDELRPLIPV LEEYKADAKL VLQFKEEVQN LTSVLNELQE EIGAYDYDEL QSRVSNLEER LRACMQKLAC GKLTGISDPV T
Positive Samples: Mouse brain, MCF7, A-549, SW480
Cellular Location: Cell junction, Cell projection, Endoplasmic reticulum, Perikaryon, axon, synapse
Target Information
The Olfactomedin family comprises a diverse group of secreted glycoproteins, including OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin, and myocilin. These proteins are implicated in the development of the nervous system.
OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse embryos (E8–10), and later in brain tissue and the zone of polarizing activity in the limb. Overexpression of OLFM1 causes excess neural crest emigration and prolonged neural crest production. OLFM2 participates in the regulation of anterior nervous system development. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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