Thermo Fisher Scientific Bax Monoclonal Antibody (BAX, 962)
인간 및 영장류 시료에 반응하는 BAX 단클론 항체로, 세포자멸사 연구에 적합합니다. IHC 및 유세포분석에 사용 가능하며, 비결합형 액상 형태로 제공됩니다. 단백질 A/G 정제, 4°C 보관, 연구용 전용 제품입니다.
- 카탈로그번호
- 581-MSM2-P0
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BAX, 962 |
| Immunogen | Recombinant full-length human BAX protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- This antibody does not react with Mouse or Rat.
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
BAX is a member of the Bcl-2 family and plays an important role in the regulation of apoptosis. While Bcl-2 is anti-apoptotic, BAX functions as a pro-apoptotic protein. Apoptosis regulation involves homo- and heterodimerization of BAX and Bcl-2 isoforms.
The Bax gene encodes isoforms such as Bax alpha (21 kDa) and Bax beta (24 kDa). Both contain BH1, BH2, and BH3 domains, but Bax beta has a unique carboxyl terminus lacking a hydrophobic transmembrane domain.
Overexpression of BAX promotes cell death through dimerization with other BCL-2 family proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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