Thermo Fisher Scientific CD169 Chimeric Recombinant Rat Monoclonal Antibody (3D6.112)
마우스 CD169를 특이적으로 인식하는 키메라 재조합 랫트 단클론 항체. Western blot, IHC, Flow Cytometry 등 다양한 응용에 적합. Protein A 정제 및 PBS 버퍼에 1 mg/mL 농도로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3D6.112 |
| Immunogen | Spleen cells from AO rats immunised with thioglycollate-elicted murine peritoneal macrophages (TPM) that had been cultured in mouse serum to induce sheep erythrocyte receptor (SER). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074252 |
Product Specific Information
This antibody specifically recognizes mouse CD169, a 180–185 kDa member of the Siglec family of macrophage-specific cell adhesion and endocytic receptors that interact with sialylated glycans. CD169 is expressed on subsets of macrophages found in the spleen, liver, lymph node, and bone marrow, and can also be detected on monocytes in the bone marrow and periphery.
Target Information
The siglecs are a family of membrane-bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22, and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule expressed on activated macrophages in chronic inflammation and tumors.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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