Thermo Fisher Scientific Amyloid beta precursor protein Polyclonal Antibody
Amyloid beta precursor protein(APP)에 특이적인 Goat Polyclonal Antibody로, WB 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, 장기보관 시 -20°C 권장. Alzheimer’s disease 연구 등 신경학적 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:1,000–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Goat / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 650–700 of human APP 695 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: APP.
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1. APP is essential for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with several isoforms resulting from alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques — a key histopathologic feature of Alzheimer’s disease. Abnormal APP processing is implicated in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 파일: OSA00119W-100UL_Amyloid_Precursor_Protein_P05067-1_Goat.svg, OSA00119W-100UL_Amyloid_Precursor_Protein_P05067-1_Goat_PDP.jpeg)
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