Thermo Fisher Scientific Human LRFN1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the carboxy terminus of human LRFN1.
PEP-0813 can be used as a blocking peptide with polyclonal antibody PA5-20698.

Target Information

LRFN1 is a member of a family of five transmembrane glycoproteins highly expressed in neuronal tissues.
LRFN proteins share a leucine-rich repeat (LRR)–immunoglobulin-like (Ig)–fibronectin type III (Fn)–transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family.
Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells.
LRFN1, -2, and -4 bind to PDZ domains of postsynaptic PSD95, redistributing PSD95 to the cell periphery.
It has been suggested that Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.
At least two isoforms of LRFN1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.