Thermo Fisher Scientific Human CDIP1 Synthetic Peptide
인간 CDIP1 단백질의 중심부 19개 아미노산 서열로 구성된 합성 펩타이드로, 폴리클로날 항체 PA5-20697의 블로킹 펩타이드로 사용 가능. p53 관련 세포사멸 경로 연구에 적합하며, 정제된 액상 형태로 제공. 연구용 전용 제품.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the center of human CDIP.
PEP-0812 can be used as a blocking peptide with polyclonal antibody PA5-20697.
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers.
CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway.
CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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