Thermo Fisher Scientific RED Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HepG2
• Predicted reactivity: Mouse (96%), Rat (96%), Chicken (87%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (97%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is expressed in a significantly higher proportion of melanomas than Spitz nevi and in metastatic melanomas more than in thin melanomas.
IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.