Thermo Fisher Scientific CK2 alpha-2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CSNK2A2.

Target Information

Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukaryotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing two alpha or alpha-prime subunits (or one of each) and two beta subunits. The function of beta subunits is unknown, and the alpha subunit is the catalytic unit.
CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha′) in a homomeric or heteromeric conformation. Whilst the alpha- and alpha′-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha′-subunit.
CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI3K signaling pathway via the phosphorylation of Akt.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.