Thermo Fisher Scientific CK2 alpha-2 Polyclonal Antibody
Human CSNK2A2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA, IP 등 다양한 응용에 적합합니다. 보존제가 없으며, 고순도의 Protein A 및 Antigen affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA580507
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 1–4 µL/mg of lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CSNK2A2 Protein (Met1–Arg350) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787812 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CSNK2A2.
Target Information
Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukaryotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing two alpha or alpha-prime subunits (or one of each) and two beta subunits. The function of beta subunits is unknown, and the alpha subunit is the catalytic unit.
CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha′) in a homomeric or heteromeric conformation. Whilst the alpha- and alpha′-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha′-subunit.
CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI3K signaling pathway via the phosphorylation of Akt.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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