Thermo Fisher Scientific Phospho-c-Cbl (Tyr700) Polyclonal Antibody
Phospho-c-Cbl (Tyr700) 항체로 인간 시료에 반응하며, Western Blot 및 ELISA에 적합. Rabbit IgG 폴리클로날 형태로 고순도 정제. 세포막 및 세포질 내 c-Cbl 단백질 신호 조절 연구에 활용 가능.
- 카탈로그번호
- PA5121300
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around Y700 of human CBL (NP_005179.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.09 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914872 |
Product Specific Information
- Positive test controls: Jurkat
- Target localization: Cell membrane, Cytoplasm
- Immunogen sequence: TEYMT
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed. Cbl-c can ubiquitinate activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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