Thermo Fisher Scientific ALKBH8 Polyclonal Antibody
인간 ALKBH8 단백질의 N-말단 펩타이드(aa 141-190)를 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, Protein A로 정제된 액상 형태. PBS + sucrose buffer로 보관하며 -20°C에서 안정적 유지.
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Applications
- Western Blot (WB)
Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human ALKBH8 (aa 141–190) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2606160 |
Product Specific Information
Peptide Sequence:
EEIISSEEEK MLLESVDWTE DTDNQNSQKS LKHRRVKHFG YEFHYENNNVSequence Homology:
Cow: 86%
Dog: 79%
Guinea Pig: 86%
Horse: 86%
Human: 100%
Mouse: 79%
Pig: 93%
Rabbit: 79%
Rat: 86%
Target Information
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys).
Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly).
Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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