Thermo Fisher Scientific PCP4 Monoclonal Antibody (CL5306)
PCP4 단백질을 인식하는 Mouse IgG1 단클론 항체로, 인간·마우스·랫트 시료에 반응합니다. IHC(P) 실험에 적합하며, Protein A로 정제된 액상 제품입니다. 뇌 신경세포 내 칼모듈린 조절 연구 및 신경퇴행성 질환 연구에 활용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL5306 |
| Immunogen | Recombinant Protein corresponding to Human PCP4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.70 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848932 |
Product Specific Information
Immunogen sequence:
GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas and neurodegenerative disorders such as Alzheimer’s disease and Huntington’s disease. Overexpression of PCP-4 is also associated with cerebellar hypoplasia, a key feature of Down syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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