Thermo Fisher Scientific KMT2D Monoclonal Antibody (CL5346)
인간 KMT2D 단백질을 인식하는 mouse IgG1 단일클론 항체로, ICC/IF에 2–10 µg/mL 농도로 사용 가능. Protein A 정제, PBS/glycerol buffer, 4°C 또는 -20°C 보관. 연구용 전용 시약으로 Kabuki 증후군 관련 연구에 적합.
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Applications
- Immunocytochemistry (ICC/IF): 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL5346 |
| Immunogen | Recombinant protein corresponding to Human KMT2D (UniProt ID: O14686-1, antigen range: 4363–4491) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848934 |
Product Specific Information
Immunogen sequence:
AQLADTLFSK GLGPWDPPDN LAETQKPEQS SLVPGHLDQV NGQVVPEASQ LSIKQEPREE PCALGAQSVK REANGEPIGA PGTSNHLLLA GPRSEAGHLL LQKLLRAKNV QLSTGRGSEG LRAEINGHI
Target Information
KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me), a marker for epigenetic transcriptional activation. It acts as a coactivator for estrogen receptors (ESR1) and participates in chromatin organization, silencing, oocyte growth, and cell proliferation.
Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1), leading to congenital mental retardation.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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