Thermo Fisher Scientific LGR5 Monoclonal Antibody (OTI2A2), TrueMAB
LGR5 단백질을 인식하는 마우스 단클론 항체로 Western blot, IHC, ICC, Flow cytometry 및 Immunoprecipitation에 적합합니다. 인간 및 마우스 반응성을 가지며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific LGR5 Monoclonal Antibody (OTI2A2), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2 µg/500 µL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 250–550 of human LGR5 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | 0 |
Available Conjugated Formats
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from human germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) constitute one of the largest families of signaling molecules, sharing a seven-transmembrane helix structure and existing in both active and inactive forms.
GPCRs are involved in diverse signaling pathways mediated by G-proteins and downstream effectors. Negative regulation mechanisms of GPCRs have significant physiological implications and are key targets in pharmacological research.
Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which dominate mental health and allergy treatment markets.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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