Thermo Fisher Scientific RIG-I Polyclonal Antibody
RIG-I 단백질을 인식하는 염소 유래 폴리클로날 항체로, 인간 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능하며, 0.5 mg/mL 농도의 액상 형태입니다. 바이러스 RNA 인식 및 선천 면역 연구에 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KDFHFEKIPFDPAE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932941 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in the detection of viral double-stranded RNA (dsRNA). Together with MDA5, RIG-I activates innate immune responses by recognizing viral RNA. Both proteins are RNA helicases with overlapping and distinct functions.
RIG-I is activated by short dsRNAs lacking a 5′-triphosphate end, while MDA5 responds to long dsRNAs. Upon activation, RIG-I signals through IPS-1, leading to activation of transcription factors NF-κB and IRF-3 and inducing apoptosis, cytokine signaling, and inflammation.
RIG-I plays a critical role in immune responses against influenza A/B, respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a negatively regulates RIG-I-dependent antiviral signaling by targeting TRAF6, IRAK1, and IRAK2. Recent studies also suggest RIG-I involvement in cytosolic DNA detection via RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-142289_RIG-I_O95786-1_Goat.svg, PA5-142289_RIG-I_O95786-1_Goat_PDP.jpeg)
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