Thermo Fisher Scientific CTCF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.

Target Information

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on DNA. It can bind to HAT- and HDAC-containing complexes, thereby influencing transcriptional activation or repression respectively.
It is a multifunctional protein involved in:

• Transactivation of APPB gene
• Silencing of c-myc gene
• Insulation of human beta-globin and DMI myotonic dystrophy locus
• Imprinting control of IGF2 and H19 regions

CTCF has also been shown to regulate transcription of Pax6 and IRAK2 promoter, opening a therapeutic avenue. Mutations in this gene are associated with invasive breast cancers, prostate cancers, and Wilms’ tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.