Thermo Fisher Scientific SURF1 Polyclonal Antibody
SURF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western Blot과 Immunocytochemistry에 적합하며, 고순도 Affinity chromatography로 정제되었습니다. 미토콘드리아 복합체 IV 연구에 활용됩니다.
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Thermo Fisher Scientific SURF1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SURF1 (Accession Q15526), corresponding to amino acid residues Y161–E211 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818229 |
Product Specific Information
Antibody detects endogenous levels of total SURF1.
Target Information
The SURF-1 protein plays a vital role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. It is expressed in the inner mitochondrial membrane. Mutations in the SURF-1 gene cause cytochrome c oxidase complex IV deficiency, leading to Leigh syndrome—a severe neurological disorder characterized by necrotic lesions in subcortical brain regions. SURF-1 mutations are associated with high embryonic lethality and early postnatal mortality, as well as muscle weakness and motor performance deficits. Morphological abnormalities in heart, brain, and skeletal muscle frequently occur due to SURF-1 mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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