Thermo Fisher Scientific CTNNA3 Polyclonal Antibody
CTNNA3 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 실험에 적합. 인간, 마우스, 랫트 시료에 반응하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관되며 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNA3 (Accession Q9UI47), corresponding to amino acid residues S502–T552 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854074 |
Product Specific Information
This antibody detects endogenous levels of total CTNNA3.
Target Information
Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, with the highest levels observed in the heart. Immunohistochemical analysis showed human alphaT-catenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of the testis.
AlphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins, indicating its role in forming specific cell-cell contacts in muscle cells.
The encoded protein has a predicted size of approximately 100 kDa and shows about 57% amino acid identity with other alpha-catenins. In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was demonstrated by co-immunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not cross-react with alphaE-catenin or alphaN-catenin in Western blot analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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