Thermo Fisher Scientific CTHRC1 Polyclonal Antibody
CTHRC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인체, 마우스, 랫트 반응성. WB 및 IHC(P) 실험에 적합. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTHRC1 (Accession Q96CG8), corresponding to amino acid residues F86–A136 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854073 |
Product Specific Information
Antibody detects endogenous levels of total CTHRC1.
Target Information
The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein transiently expressed in the arterial wall in response to injury. It contributes to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration.
CTHRC1 is highly expressed in multiple human cancers, including pancreatic cancer, where it plays a significant role in tumor progression and metastasis by regulating migration and adhesion of tumor cells.
Overexpression of CTHRC1 can serve as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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