Thermo Fisher Scientific RAPGEF5 Polyclonal Antibody
RAPGEF5 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트에 반응하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RAPGEF5 (Accession Q92565), corresponding to amino acid residues F521–E571 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851243 |
Product Specific Information
This antibody detects endogenous levels of total RAPGEF5.
Target Information
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.
Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas, and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse, and rat. The gene encoding Repac maps to human chromosome 7p15.3, with high expression of this region linked to positive response to erlotinib therapy for non-small-cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-101811_RAPGEF5_Q92565-1_Rabbit.svg, PA5-101811_RAPGEF5_Q92565-1_Rabbit_PDP.jpeg)
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