Thermo Fisher Scientific PCDHGA2 Monoclonal Antibody (2A7)

Applications

Product Specifications

Product Specific Information

Protein sequence:

SGTSRICVKV LDANDNAPVF TQPEYRISIP ENTLVGTRIL TVTATDADEG YYAQVVYFLE KSPGETSEVF ELKSTSGELT IIKDLDYEDA TFHEIDIEAQ DGPGLLTRA

Target Information

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies:

• Subfamily A: 12 genes
• Subfamily B: 7 genes and 2 pseudogenes
• Subfamily C: 3 genes

The tandem array of 22 large, variable region exons are followed by a constant region containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.