Thermo Fisher Scientific Phospho-Androgen Receptor (Ser94) Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.

AR plays a key role in:

• Development and function of male reproductive organs (prostate, epididymis)
• Regulation in nonreproductive organs (muscle, hair follicles, brain)
• MAP kinase pathway modulation and phosphorylation state changes

Abnormalities in AR signaling are associated with diseases such as:

• Prostate cancer
• Kennedy’s disease
• Male infertility
• Complete androgen insensitivity (CAIS)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.