Thermo Fisher Scientific Plasminogen Activator Inhibitor 2 Polyclonal Antibody

Thermo Fisher Scientific Plasminogen Activator Inhibitor 2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid freeze/thaw cycles. Centrifuge if not clear after standing at room temperature. Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against human PAI-2 protein and shows reactivity against human and primate PAI-2 based on 94% sequence homology. Reactivity with other species is unknown.

Target Information

PAI-2 is an inhibitory serpin mainly expressed in keratinocytes, activated monocytes, and placental trophoblasts. It exists as a 47 kDa nonglycosylated intracellular protein and can be secreted as a 60 kDa glycoprotein. Both forms effectively inhibit urokinase-type plasminogen activator (uPA).
PAI-2 can form dormant polymers spontaneously under physiological conditions, possibly regulating controlled release from producing cells. Plasma levels are typically low except during pregnancy and certain leukemias. Placental secretion during the third trimester increases PAI-2 levels significantly.
PAI-2 plays a vital role in protecting the placenta, preventing metastatic spread of neck, lung, and breast cancers, inhibiting keratinocyte proliferation, and participating in innate immune responses during viral infection.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.