Thermo Fisher Scientific NAG-1 Polyclonal Antibody
Thermo Fisher Scientific의 NAG-1 Polyclonal Antibody는 인간 및 생쥐 NAG-1 단백질의 C-말단에 특이적으로 반응하는 친화 정제 항체입니다. WB, IHC, ELISA, IP 등 다양한 응용에 적합하며, 암 억제 단백질 GDF-15 연구에 활용됩니다. -20°C 보관 권장.
- 카탈로그번호
- 600-401-B07x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NAG-1 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:250–1:500 |
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | 1:300,000 |
| Immunoprecipitation (IP) | 1:2,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity purified antibody prepared by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminal end of human NAG-1 protein. A cysteine residue was added to facilitate coupling to KLH. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody reacts with the C-terminus of endogenous NAG-1 protein from human and mouse tissues.
A BLAST analysis suggests reactivity with NAG-1 from chimpanzee and macaque based on 100% homology.
Partial reactivity is expected against rat (86% homology).
Cross-reactivity with NAG-1 from other sources has not been determined.
Target Information
GDF-15 belongs to the TGF-beta cytokine family, which plays an important role in prenatal development, postnatal growth, and tissue remodeling.
It is expressed predominantly in the placenta and to a lesser extent in other tissues.
Presence in amniotic fluid and elevated levels in pregnant women suggest involvement in gestation and embryonic development.
GDF-15 generally exerts tumor suppressive activities and is a major factor produced in response to p53 pathway activation.
Serum levels of GDF-15 correlate with progression of several tumor types including colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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